| CNV analysis using TaqMan copy number assays. | |
| | |
MedLine Citation:
|
PMID: 20891030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Copy number variations are important polymorphisms that can influence the expression of genes within and close to the rearranged region. This allows transcription levels to be higher or lower than those that can be achieved by control of transcription of a single copy. Recently, copy number variations have been associated with genetic diseases such as cancer, immune diseases, and neurological disorders. TaqMan copy number assays are designed to detect and measure copy number variation in the human genome using real-time polymerase chain reaction and unquenching of fluorescent probes for the target sequence. |
| | |
Authors:
|
Ping Mayo; Toinette Hartshorne; Kelly Li; Chara McMunn-Gibson; Kylee Spencer; Nathalie Schnetz-Boutaud |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] Volume: Chapter 2 ISSN: 1934-8258 ISO Abbreviation: Curr Protoc Hum Genet Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101287858 Medline TA: Curr Protoc Hum Genet Country: United States |
Other Details:
|
Languages: eng Pagination: Unit2.13 Citation Subset: IM |
Affiliation:
|
Center for Human Genetic Research, Vanderbilt University, Nashville, Tennessee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
DNA Copy Number Variations* Genome, Human* Humans Polymerase Chain Reaction / methods* Polymorphism, Genetic Polymorphism, Single Nucleotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular analysis of gene rearrangements and mutations in acute leukemias and myeloproliferative ne...
Next Document: Diagnosis of cryptic chromosomal syndromes by fluorescence in situ hybridization (FISH).