Document Detail


CNS regeneration: only on one condition.
MedLine Citation:
PMID:  19515349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammalian CNS is usually not capable of regeneration. However, conditioning dorsal root ganglion neurons by first lesioning their peripheral axons allows for regeneration of their central axons later on within the spinal cord. New work shows that, even if the sequence of lesioning is reversed, regeneration through the CNS lesion can rapidly occur under certain conditions.
Authors:
Jerry Silver
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Current biology : CB     Volume:  19     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-11     Completed Date:  2009-10-13     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R444-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology,  ultrastructure
Central Nervous System / injuries,  pathology,  physiology*
Ganglia, Spinal / physiology*,  ultrastructure
Nerve Regeneration / physiology*
Rats
Sensory Receptor Cells / physiology*,  ultrastructure
Grant Support
ID/Acronym/Agency:
R01 NS060767/NS/NINDS NIH HHS; R01 NS060767-02/NS/NINDS NIH HHS
Comments/Corrections
Comment On:
Curr Biol. 2009 Jun 9;19(11):930-6   [PMID:  19409789 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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