| CNS regeneration: clinical possibility or basic science fantasy? | |
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MedLine Citation:
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PMID: 12948453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following injury to the CNS, severed axons undergo a phase of abortive sprouting in the vicinity of the wound, but do not spontaneously re-grow or regenerate. From a long history of attempts to stimulate regeneraion, a major strategy that has been developed clinically is the implantation of tissue into denervated target regions. Unfortunately trials have so far not borne out the promise that this would prove a useful therapy for disorders such as Parkinson's disease. Many strategies have also been developed to stimulate the regeneration of axons across sites of injury, particularly in the spinal cord. Animal data have demonstrated that some of these approaches hold promise and that the spinal cord has a remarkable degree of intrinsic plasticity. Attempts are now being made to utilize experimental techniques in spinal patients. |
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Authors:
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Peter E Batchelor; David W Howells |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 10 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2009-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 523-34 Citation Subset: IM |
Affiliation:
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Departments of Medicine and Neurology, University of Melbourne, Austin and Repatriation Medical Centre, Vic. 3084, Heidelberg, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System Diseases / physiopathology* Denervation Humans Inflammation / physiopathology Macrophages / physiology Microglia / physiology Models, Animal Nerve Fibers / physiology Nerve Regeneration / physiology* Parkinson Disease / physiopathology, surgery Peripheral Nerves / transplantation Spinal Cord Diseases / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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