Document Detail

CNS midline cells influence the division and survival of lateral glia in the Drosophila nervous system.
MedLine Citation:
PMID:  17457927     Owner:  NLM     Status:  MEDLINE    
Central nervous system (CNS) midline cells are essential for identity determination and differentiation of neurons in the Drosophila nervous system. It is not clear, however, whether CNS midline cells are also involved in the development of lateral glial cells. The roles of CNS midline cells in lateral glia development were elucidated using general markers for lateral glia, such as glial cell missing and reverse polarity, and specific enhancer trap lines labeling the longitudinal, A, B, medial cell body, peripheral, and exit glia. We found that CNS midline cells were necessary for the proper expression of glial cell missing, reverse polarity, and other lateral glia markers only during the later stages of development, suggesting that they are not required for initial identity determination. Instead, CNS midline cells appear to be necessary for proper division and survival of lateral glia. CNS midline cells were also required for proper positioning of three exit glia at the junction of segmental and intersegmental nerves, as well as some peripheral glia along motor and sensory axon pathways. This study demonstrated that CNS midline cells are extrinsically required for the proper division, migration, and survival of various classes of lateral glia from the ventral neuroectoderm.
So Hee Kim; Hyeon Ju Kim; Soo Youn Kim; Sang-Hak Jeon; Sang Hee Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  45     ISSN:  1526-954X     ISO Abbreviation:  Genesis     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-74     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Chemistry, Konkuk University, Seoul, Korea.
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MeSH Terms
Animals, Genetically Modified
Cell Division
Cell Movement
Cell Survival
Central Nervous System / cytology*,  embryology*,  metabolism
DNA-Binding Proteins / genetics
Drosophila / cytology*,  embryology*,  genetics
Drosophila Proteins / genetics
Gene Expression Regulation, Developmental
Genes, Insect
Homeodomain Proteins / genetics
In Situ Hybridization
Lac Operon
Neuroglia / cytology,  metabolism
Transcription Factors / genetics
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/GCM protein, Drosophila; 0/Homeodomain Proteins; 0/Transcription Factors; 0/repo protein, Drosophila

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