| CNS leptin and insulin action in the control of energy homeostasis. | |
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MedLine Citation:
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PMID: 21070248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The obesity and diabetes pandemics have made it an urgent necessity to define the central nervous system (CNS) pathways controlling body weight, energy expenditure, and fuel metabolism. The pancreatic hormone insulin and the adipose tissue-derived leptin are known to act on diverse neuronal circuits in the CNS to maintain body weight and metabolism in a variety of species, including humans. Because these homeostatic circuits are disrupted during the development of obesity, the pathomechanisms leading to CNS leptin and insulin resistance are a focal point of research. In this review, we summarize the recent findings concerning the mechanisms and novel neuronal mediators of both insulin and leptin action in the CNS. |
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Authors:
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Bengt F Belgardt; Jens C Brüning |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-11-11 |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1212 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-14 Revised Date: 2010-12-30 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 97-113 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, Zülpicher Strasse 47a, Cologne, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / drug effects, genetics, physiology Central Nervous System / drug effects, metabolism* Energy Intake / drug effects, genetics, physiology Energy Metabolism / drug effects, genetics, physiology* Homeostasis / drug effects, genetics, physiology* Humans Insulin / metabolism, pharmacology, physiology* Leptin / genetics, metabolism*, physiology Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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