Document Detail


CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices.
MedLine Citation:
PMID:  2899308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX; FG 9065) is a new excitatory amino acid antagonist. In the spinal cord it has been reported to selectively block responses to acidic amino acids acting at receptors of the non-N-methyl-D-aspartate (non-NMDA) type. Here we report that in rat hippocampal slices bathed in Mg2+-free medium 10 microM CNQX reversibly blocks responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA. The synaptic response evoked by low frequency stimulation of Schaffer collateral-commissural fibres in 1 mM Mg2+-containing medium is completely blocked by this concentration of CNQX. In contrast the synaptic response evoked in Mg2+-free medium is not fully blocked by CNQX. The CNQX-insensitive component is, however, abolished by addition of a selective NMDA antagonist. The use of CNQX has allowed for the first time selective synaptic activation of NMDA receptors in the hippocampus.
Authors:
J F Blake; M W Brown; G L Collingridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  89     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-08-22     Completed Date:  1988-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy, School of Medical Sciences, University of Bristol, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Hippocampus / drug effects*,  physiology
Ibotenic Acid / analogs & derivatives,  physiology
Kainic Acid / physiology
Oxadiazoles / physiology
Quinoxalines / physiology*
Quisqualic Acid
Rats
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter / physiology*
Synapses / drug effects*,  physiology
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Chemical
Reg. No./Substance:
0/Oxadiazoles; 0/Quinoxalines; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 2552-55-8/Ibotenic Acid; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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