Document Detail

CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice.
MedLine Citation:
PMID:  18007188     Owner:  NLM     Status:  MEDLINE    
Kaolin-induced writhing reaction is a simple and convenient model of bradykinin-induced pain for assessment of analgesic actions. In this study, we demonstrated that the number of kaolin-induced writhing reaction was fluctuated in a circadian manner that peaked at the end of the resting period (dusk) and reduced during the active (dark) period in mice. Circadian rhythm of the writhing intensity was completely phase-shifted by a time-imposed restricted feeding. On the other hand, 24 h of food deprivation did not affect the writhing intensity, suggesting that the endogenous clock that can be entrained to the scheduled feeding is responsible to the circadian intensity of the writhing reaction. Day/night fluctuation of the writhing intensity was completely abolished and the writhing reaction was significantly reduced in the circadian clock deficient Clock-mutant mice, although the kaolin-induced bradykinin production and blood pressure suppression were not affected in these mutant mice. Our present study suggested that the circadian variation of the pain sensitivity is governed by the food-entrainable endogenous clock and by the circadian clock molecules in mammals.
Katsutaka Oishi; Naoki Ohkura; Hiroyoshi Sei; Juzo Matsuda; Norio Ishida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  18     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1925-8     Citation Subset:  IM    
Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
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MeSH Terms
Appetite Regulation / physiology
Biological Clocks / drug effects,  physiology*
Blood Pressure / drug effects,  physiology
Bradykinin / metabolism
CLOCK Proteins
Circadian Rhythm / drug effects,  physiology*
Food Deprivation / physiology
Hypothalamus / metabolism,  secretion
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Neurologic Mutants
Mutation / genetics
Pain / chemically induced,  metabolism*,  physiopathology
Pain Measurement / drug effects
Pain Threshold / drug effects,  physiology*
Trans-Activators / genetics,  metabolism*
Reg. No./Substance:
0/Antidiarrheals; 0/Trans-Activators; 1332-58-7/Kaolin; 58-82-2/Bradykinin; EC Proteins; EC protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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