Document Detail


CLB5-dependent activation of late replication origins in S. cerevisiae.
MedLine Citation:
PMID:  9734354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Replication origins in chromosomes are activated at specific times during the S phase. We show that the B-type cyclins are required for proper execution of this temporal program. clb5 cells activate early origins but not late origins, explaining the previously described long clb5 S phase. Origin firing appears normal in cIb6 mutants. In clb5 clb6 double mutant cells, the late origin firing defect is suppressed, accounting for the normal duration of the phase despite its delayed onset. Therefore, Clb5p promotes the timely activation of early and late origins, but Clb6p can activate only early origins. In clb5 clb6 mutants, the other B-type cyclins (Clb1-4p) promote an S phase during which both early and late replication origins fire.
Authors:
A D Donaldson; M K Raghuraman; K L Friedman; F R Cross; B J Brewer; W L Fangman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular cell     Volume:  2     ISSN:  1097-2765     ISO Abbreviation:  Mol. Cell     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2008-10-31    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-82     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Washington, Seattle 98195-7360, USA. adonaldson@bad.dunde.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Fungal / genetics
Cyclin B*
Cyclins / genetics,  metabolism*
DNA Replication / genetics
DNA, Fungal / biosynthesis,  genetics
Fungal Proteins / genetics,  metabolism*
Kinetics
Models, Biological
Mutation
Replication Origin*
S Phase / genetics
Saccharomyces cerevisiae / cytology,  genetics*,  metabolism*
Saccharomyces cerevisiae Proteins*
Grant Support
ID/Acronym/Agency:
18926//PHS HHS
Chemical
Reg. No./Substance:
0/CLB5 protein, S cerevisiae; 0/CLB6 protein, S cerevisiae; 0/Cyclin B; 0/Cyclins; 0/DNA, Fungal; 0/Fungal Proteins; 0/Saccharomyces cerevisiae Proteins

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