Document Detail


CKbeta8, a novel CC chemokine that predominantly acts on monocytes.
MedLine Citation:
PMID:  9187369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the biological properties of a new human CC chemokine, CKbeta8, consisting of 99 amino acids including six cysteines. CKbeta8 mRNA transcripts were induced in monocytes by IL-1beta and, to a lesser extent, by IFNgamma, and were detected in RNA extracted from normal human liver and gastrointestinal tract. CKbeta8 is chemotactic for monocytes, but is inactive on IL-2 conditioned T lymphocytes, eosinophils and neutrophils. Desensitization experiments indicate that CKbeta8 and MIP-1beta completely share receptors on monocytes and that the CKbeta8 receptor, which appears to differ from the known ones, is also recognized by MCP-1, MCP-2, MCP-3, MCP-4, MIP-1alpha and RANTES.
Authors:
U Forssmann; M B Delgado; M Uguccioni; P Loetscher; G Garotta; M Baggiolini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  408     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-14     Completed Date:  1997-07-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Affiliation:
Theodor Kocher Institute, University of Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / metabolism
Amino Acid Sequence
Blotting, Northern
Calcium / analysis,  metabolism
Chemokines / chemistry*,  genetics,  pharmacology*
Chemokines, CC*
Chemotaxis, Leukocyte
Cloning, Molecular
Cytochalasin B / pharmacology
Eosinophils / drug effects
Fluorescent Dyes / metabolism
Fura-2 / metabolism
Gene Expression Regulation
Humans
Interleukin-2 / pharmacology
Molecular Sequence Data
Monocytes / physiology*
Receptors, Cytokine / metabolism
Sequence Alignment
Sequence Analysis
T-Lymphocytes / drug effects
Virulence Factors, Bordetella / pharmacology
Chemical
Reg. No./Substance:
0/CCL23 protein, human; 0/Chemokines; 0/Chemokines, CC; 0/Fluorescent Dyes; 0/Interleukin-2; 0/Receptors, Cytokine; 0/Virulence Factors, Bordetella; 14930-96-2/Cytochalasin B; 7440-70-2/Calcium; 96314-98-6/Fura-2; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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