| CKD and sudden cardiac death: epidemiology, mechanisms, and therapeutic approaches. | |
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MedLine Citation:
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PMID: 23100219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple studies demonstrate a strong independent association between CKD and cardiovascular events including death, heart failure, and myocardial infarction. This review focuses on recent clinical studies that expand this spectrum of adverse cardiovascular events to include ventricular arrhythmias and sudden cardiac death. In addition, experimental models suggest structural remodeling of the heart and electrophysiologic changes in this population. These processes may explain the increased arrhythmic risk in kidney disease and aid in identifying patients who are at higher risk for sudden cardiac death. Finally, we review here the data to support the use of pharmacologic and device-based therapies for both the primary and secondary prevention of sudden cardiac death. |
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Authors:
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Isaac R Whitman; Harold I Feldman; Rajat Deo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-10-25 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 23 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-03 Completed Date: 2013-02-04 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1929-39 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Death, Sudden, Cardiac / epidemiology, etiology, prevention & control* Defibrillators, Implantable Humans Renal Insufficiency, Chronic / complications*, drug therapy, epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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K23DK089118/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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