Document Detail


CKD and sudden cardiac death: epidemiology, mechanisms, and therapeutic approaches.
MedLine Citation:
PMID:  23100219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple studies demonstrate a strong independent association between CKD and cardiovascular events including death, heart failure, and myocardial infarction. This review focuses on recent clinical studies that expand this spectrum of adverse cardiovascular events to include ventricular arrhythmias and sudden cardiac death. In addition, experimental models suggest structural remodeling of the heart and electrophysiologic changes in this population. These processes may explain the increased arrhythmic risk in kidney disease and aid in identifying patients who are at higher risk for sudden cardiac death. Finally, we review here the data to support the use of pharmacologic and device-based therapies for both the primary and secondary prevention of sudden cardiac death.
Authors:
Isaac R Whitman; Harold I Feldman; Rajat Deo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-25
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  23     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-04     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1929-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Death, Sudden, Cardiac / epidemiology,  etiology,  prevention & control*
Defibrillators, Implantable
Humans
Renal Insufficiency, Chronic / complications*,  drug therapy,  epidemiology
Grant Support
ID/Acronym/Agency:
K23 DK089118/DK/NIDDK NIH HHS; K23DK089118/DK/NIDDK NIH HHS
Comments/Corrections

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