Document Detail

CKD, plasma lipids, and common carotid intima-media thickness: results from the multi-ethnic study of atherosclerosis.
MedLine Citation:
PMID:  22879436     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Altered levels of atherogenic lipoproteins have been shown to be common in mild kidney dysfunction. This study sought to determine the associations between plasma lipids (including LDL particle distribution) and subclinical atherosclerosis measured by the common carotid intima-media thickness (IMT) across levels of estimated GFR (eGFR) and to assess whether inflammation modifies these associations.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Cross-sectional analyses of 6572 participants in the Multi-Ethnic Study of Atherosclerosis enrolled from 2000 to 2002 were performed.
RESULTS: CKD, defined as eGFR <60 ml/min per 1.73 m(2), was present in 853 individuals (13.0%). Associations of total cholesterol and LDL cholesterol (LDL-C) with IMT were J shaped, particularly among participants with CKD (P value for interaction, P=0.01). HDL cholesterol (HDL-C) and small-dense LDL-C were consistently and linearly associated with IMT across levels of eGFR. The results showed differences in IMT of -21.41 (95% confidence interval, -41.00, -1.57) in eGFR ≥60 and -58.49 (-126.61, 9.63) in eGFR <60 per unit difference in log-transformed HDL-C, and 4.83 (3.16, 6.50) in eGFR ≥60 and 7.48 (1.45, 13.50) in eGFR <60 per 100 nmol/L difference in small-dense LDL. Among participants with CKD, inflammation significantly modified the associations of total cholesterol and LDL-C with IMT (P values for interaction, P<0.01 and P<0.001, respectively).
CONCLUSIONS: Compared with total cholesterol and LDL-C, abnormalities in HDL-C and small-dense LDL-C are more strongly and consistently associated with subclinical atherosclerosis in CKD. Inflammation modifies the association between total cholesterol and LDL-C with IMT.
Julio A Lamprea-Montealegre; Brad C Astor; Robin L McClelland; Ian H de Boer; Gregory L Burke; Christopher T Sibley; Daniel O'Leary; A Richey Sharrett; Moyses Szklo
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Publication Detail:
Type:  Journal Article     Date:  2012-08-09
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  7     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-06-21     Revised Date:  2013-11-15    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1777-85     Citation Subset:  IM    
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
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MeSH Terms
Atherosclerosis / blood*,  pathology,  physiopathology
Carotid Intima-Media Thickness*
Cholesterol, LDL / blood
Cohort Studies
Cross-Sectional Studies
Glomerular Filtration Rate
Inflammation / physiopathology
Lipids / blood*
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Cholesterol, LDL; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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