Document Detail

CHARGE association, hyper-immunoglobulin M syndrome, and conjunctival MALT lymphoma.
MedLine Citation:
PMID:  17667624     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a case of a 5-year-old child with CHARGE association and bilateral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma treated with topical interferon-alpha. METHODS: Case report. RESULTS: A 5-year-old girl, diagnosed with nonclassical CHARGE association and hyper-immunoglobulin M (IgM) syndrome, was referred with a 2-month history of suspected purulent bilateral streptococcal conjunctivitis. Clinical symptoms did not resolve despite multiple antibiotic treatments, and her clinical course was attributed to underlying immunodeficiency. Biomicroscopy showed salmon-colored, nodular lesions occupying both fornices and caruncles. Inferior conjunctival biopsy was performed, and MALT lymphoma was diagnosed. Bilateral treatment was initiated with topical interferon-alpha, applied 3 times a day at a concentration of 5 x 10 U/m/d, for 4 months. Complete regression of symptoms and conjunctival lesions was achieved. No recurrences have been observed after 1-year follow-up. CONCLUSIONS: We report the use of topical interferon-alpha as treatment for bilateral conjunctival MALT lymphoma in a young child with CHARGE association and hyper-IgM syndrome.
Graciana Fuentes-Páez; M Antonia Saornil; José M Herreras; María Alonso-Ballesteros; Pilar Solis Sánchez; Manuel García-Tejeiro
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cornea     Volume:  26     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  864-7     Citation Subset:  IM    
Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid and Hospital Clínico Universitario, Valladolid, Spain.
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MeSH Terms
Abnormalities, Multiple*
Antineoplastic Agents / therapeutic use
Child, Preschool
Choanal Atresia / complications
Coloboma / complications
Conjunctival Neoplasms / complications*,  drug therapy
Ear / abnormalities
Genitalia, Female / abnormalities
Growth Disorders / complications
Hyper-IgM Immunodeficiency Syndrome / complications*
Interferon Alfa-2a / therapeutic use
Lymphoma, B-Cell, Marginal Zone / complications*,  drug therapy
Reg. No./Substance:
0/Antineoplastic Agents; 76543-88-9/Interferon Alfa-2a

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