Document Detail


CHARGE Association in newborns: a registry-based study.
MedLine Citation:
PMID:  10590394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CHARGE Association is a nonrandom occurrence of congenital malformations that has been described in clinical series. Reported patients have been selected on the basis of certain prior criteria. In this article, we try to identify a congenital malformation pattern corresponding to the CHARGE Association, using statistical methods and analyzing 5,260 infants with multiple malformations collected from four large registries of congenital malformations. Care was taken to identify a number of confounding characteristics that can influence the ascertainment and registration of specific congenital malformations. We have identified a cluster of malformations that generally agreed with the current clinical definition of the CHARGE Association and have added some further malformations (e.g., facial clefts). We demonstrate that others (e.g. , esophageal atresia) are probably not part of the pattern. Heart defects (H in the acronym) seems to be less helpful in identifying infants with the association. We suggest a method to select infants who probably represent the CHARGE Association for analyses of possible risk factors.
Authors:
K Källén; E Robert; P Mastroiacovo; E E Castilla; B Källén
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Teratology     Volume:  60     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-43     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Affiliation:
Tornblad Institute, University of Lund, S-223 62 Lund, Sweden. Karin.Kallen@anatom.lu.se
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / classification,  epidemiology*
Choanal Atresia / epidemiology
Cohort Studies
Coloboma / epidemiology
Congenital Abnormalities / classification,  epidemiology*
Epidemiologic Methods
Europe / epidemiology
Eye Abnormalities / epidemiology
Humans
Infant, Newborn
Registries*
Comments/Corrections
Comment In:
Teratology. 1999 Dec;60(6):332-3   [PMID:  10590393 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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