| The CHADS(2) and CHA (2)DS (2)-VASc scores predict new occurrence of atrial fibrillation and ischemic stroke. | |
| | |
MedLine Citation:
|
PMID: 23389054 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Early identification of individuals who are at risk of developing atrial fibrillation (AF) and ischemic stroke may enable a closer surveillance and thus prompt initiation of oral anticoagulation for stroke prevention. OBJECTIVE: This study sought to investigate whether congestive heart failure, hypertension, age ≥ 75 years, diabetes, previous stroke (CHADS(2)) and CHA(2)DS(2)-vascular disease, age 65-74 years, sex category (CHA(2)DS(2)-VASc) scores can predict new-onset AF and/or ischemic stroke in patients presenting with arrhythmic symptoms. METHODS AND RESULTS: We prospectively followed up 528 patients (68.5 ± 10.6 years, male 46.2 %) presented for assessment of arrhythmic symptoms but without any documented arrhythmia, including AF for development of new-onset AF and/or ischemic stroke. Their mean CHADS(2) and CHA(2)DS(2)-VASc scores on presentation were 1.3 ± 1.3 and 2.3 ± 1.5, respectively. After 6.1 years, 89 patients (16.8 %, 2.77 per 100 patient-years) had documented AF, and 65 patients (12.3 %, 2.0 per 100 patient-years) suffered stroke. Both the CHADS(2) (C statistic 0.63, 95 % confidence interval (CI) 0.58-0.67, P < 0.0001, optimal cutoff at 1) and CHA(2)DS(2)-VASc (C statistic 0.63, 95 % CI 0.59-0.67, P < 0.0001, optimal cutoff at 2) scores provided similar prediction for the new-onset AF. Similarly, CHADS(2) (C statistic 0.69, 95 % CI 0.65-0.73, P < 0.0001, optimal cutoff at 2) and CHA(2)DS(2)-VASc (C statistic 0.69, 95 % CI 0.65-0.73, P < 0.0001, optimal cutoff at 2) have compatible efficacy for stroke prediction in this Chinese population. CONCLUSION: The CHADS(2) and CHA(2)DS(2)-VASc scores can be used in patients who presented with arrhythmic symptoms to identify those who are at risk with developing new-onset clinical AF and ischemic stroke for close clinical surveillance and early intervention. |
| | |
Authors:
|
Ming-Liang Zuo; Shasha Liu; Koon-Ho Chan; Kui-Kai Lau; Boon-Hor Chong; Kwok-Fai Lam; Yap-Hang Chan; Yuk-Fai Lau; Gregory Y H Lip; Chu-Pak Lau; Hung-Fat Tse; Chung-Wah Siu |
Related Documents
:
|
18047504 - Long-term efficacy of a single course of infliximab in hidradenitis suppurativa. 10615974 - Tuberculosis of the foot. 7748214 - Every-other-week methotrexate in patients with rheumatoid arthritis. a double-blind, pl... 3690984 - A prospective study of early onset rheumatoid arthritis over fifteen years: prognostic ... 20357504 - Potential adjuvant effects of nigella sativa seeds to improve specific immunotherapy in... 19486084 - Long-term results of biofeedback treatment for faecal incontinence: a comparative study... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-7 |
Journal Detail:
|
Title: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing Volume: - ISSN: 1572-8595 ISO Abbreviation: J Interv Card Electrophysiol Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9708966 Medline TA: J Interv Card Electrophysiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spatial torsion of the ipsilateral superior and inferior pulmonary veins.
Next Document: Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular re...