Document Detail


CFL1 and Arp3 are Biomarkers for Metastasis and Poor Prognosis of Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas of Gallbladder.
MedLine Citation:
PMID:  23320827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cofilin-1 (CFL1) and Arp3 expression in 46 squamous cell and adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (ACs) were measured by using immunohistochemistry. Positive CFL1 and Arp3 expression were significantly associated with large tumor size, high TNM stage, lymph node metastasis, and decreased overall survival in both SC/ASC and AC patients (p < .001). Multivariate Cox regression analysis showed that positive CFL1 and Arp3 expression are independent poor-prognostic factors for both SC/ASC and AC patients. Our study suggested that positive CFL1 and Arp3 expression are closely related to tumor progression, metastasis, and poor prognosis of gallbladder cancer.
Authors:
Zhu-Lin Yang; Xiongying Miao; Li Xiong; Qiong Zou; Yuan Yuan; Jinghe Li; Lufeng Liang; Meigui Chen; Senlin Chen
Related Documents :
17616437 - Are peroxiredoxins tumor suppressors?
23587227 - Prognostic significance of ploidy and s-phase fraction in primary intraoral squamous ce...
23869217 - Cooperative roles of sdf-1α and egf gradients on tumor cell migration revealed by a rob...
7614457 - Cell cycle arrest and inhibition of tumor cell proliferation by the p16ink4 gene mediat...
7544737 - Detection of tumor cells in the bone marrow, peripheral blood, and apheresis products o...
2834047 - Selective amplification of the cytoplasmic domain of the epidermal growth factor recept...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Cancer investigation     Volume:  -     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University , Changsha, Hunan , P. R. China,1.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparisons of perioperative outcomes and costs between open and laparoscopic radical prostatectomy:...
Next Document:  Psychotropic Medications and the Transition Into Care: A National Data Linkage Study.