| The CEPHEUS Pan-Asian survey: high low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre. | |
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MedLine Citation:
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PMID: 23018067 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES. To evaluate attainment of low-density lipoprotein cholesterol goals among hypercholesterolaemic patients undergoing lipid-lowering drug treatment in Hong Kong and to identify potential determinants of treatment outcomes. DESIGN. Cross-sectional observational study. SETTING. A single site in Hong Kong, as part of the CEPHEUS Pan-Asian survey. PATIENTS. Subjects with hypercholesterolaemia aged 18 years or above, who had been on lipid-lowering drug treatment for at least 3 months with no dose adjustment for at least 6 weeks. RESULTS. A total of 561 such patients (mean age, 65.3; standard deviation, 9.7 years) were evaluated. Most had major cardiovascular risk factors; 534 (95.2%) of 561 patients had coronary heart disease and 534 (95.4%) of 560 patients had low-density lipoprotein cholesterol goals set at lower than 70 mg/dL. In all, 465 (82.9%) patients attained their respective low-density lipoprotein cholesterol goals. Among 75 patients who had coronary heart disease or equivalent risk, and multiple risk factors with a 10-year coronary heart disease risk of over 20%, 62 (82.7%) attained their respective low-density lipoprotein cholesterol goals. Significant predictors of low-density lipoprotein cholesterol goal attainment included the patient's baseline lipid profile (total cholesterol and low-density lipoprotein cholesterol levels), blood pressure, and drugs (statin/non-statin) used for treatment. CONCLUSIONS. Hypercholesterolaemic patients undergoing lipid-lowering drug treatment in the present Hong Kong study were able to achieve a very high attainment rate for the low-density lipoprotein cholesterol goal, despite the fact that most of them had major cardiovascular risk factors. |
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Authors:
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R Hw Chan; P H Chan; K Kw Chan; S Cc Lam; J J Hai; M Kl Wong; F Cc Tam; L Lam; C Ws Chan; Y M Lam; D Cw Siu; H F Tse; S Wl Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine Volume: 18 ISSN: 1024-2708 ISO Abbreviation: Hong Kong Med J Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512509 Medline TA: Hong Kong Med J Country: China |
Other Details:
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Languages: eng Pagination: 395-406 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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