| CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. | |
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MedLine Citation:
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PMID: 11595183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations. In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes. CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals. |
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Authors:
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T L Gumienny; E Brugnera; A C Tosello-Trampont; J M Kinchen; L B Haney; K Nishiwaki; S F Walk; M E Nemergut; I G Macara; R Francis; T Schedl; Y Qin; L Van Aelst; M O Hengartner; K S Ravichandran |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 107 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2001-12-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 27-41 Citation Subset: IM |
Affiliation:
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Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11743, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF398883; AF398884; AF398885; AF398886 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing* Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis elegans / cytology, genetics, physiology* Caenorhabditis elegans Proteins* Carrier Proteins / chemistry, genetics, metabolism* Cell Line Cell Movement / physiology* Cell Surface Extensions / metabolism Cytoskeletal Proteins* Cytoskeleton / metabolism Flow Cytometry Genes, Helminth Genes, Reporter Gonads / growth & development Helminth Proteins / genetics, metabolism* Humans Male Mice Microscopy, Fluorescence Molecular Sequence Data Phagocytosis / physiology* Protein Kinases / metabolism Proteins / metabolism Proto-Oncogene Proteins* Proto-Oncogene Proteins c-crk Recombinant Fusion Proteins / genetics, metabolism Sequence Alignment Signal Transduction / physiology Tissue Distribution rac GTP-Binding Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM52540/GM/NIGMS NIH HHS; GM63310/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/CED-12 protein, C elegans; 0/Caenorhabditis elegans Proteins; 0/Carrier Proteins; 0/Cytoskeletal Proteins; 0/DOCK1 protein, human; 0/ELMO2 protein, human; 0/ELMO3 protein, human; 0/Elmo2 protein, mouse; 0/Helminth Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-crk; 0/Recombinant Fusion Proteins; EC 2.7.-/Protein Kinases; EC 3.6.5.2/rac GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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