| CDT values are not influenced by epithelial cell apoptosis in chronic alcoholic patients-preliminary results. | |
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MedLine Citation:
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PMID: 15365311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbohydrate-deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol-dependent patients using serum contents of caspase-related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage. |
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Authors:
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Katrin Ramskogler; Markus Brunner; Ines Hertling; Alexander Dvorak; Nestor Kapusta; Claus Krenn; Bernhard Moser; Georg Roth; Otto Michael Lesch; Hendrik Jan Ankersmit; Henriette Walter |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 28 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-14 Completed Date: 2004-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: United States |
Other Details:
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Languages: eng Pagination: 1396-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Medical University of Vienna, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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blood* Apoptosis / physiology* Epithelial Cells / metabolism* Humans Middle Aged Statistics, Nonparametric Transferrin / analogs & derivatives*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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