Document Detail

CDKs and CKIs: molecular targets for tissue remodelling.
MedLine Citation:
PMID:  12402499     Owner:  NLM     Status:  MEDLINE    
Effective tissue remodelling is essential to the survival of adult organs. Many of the signalling pathways that control these cellular decisions are regulated by nuclear interactions of cell-cycle proteins. Molecules that target cyclin-dependent kinases (CDKs) or CDK inhibitors (CKIs) represent a new class of therapeutic agents that influence tissue remodelling in several organ systems. An understanding of their cell-specific functions is leading to the development of exciting and bold approaches to the treatment cancer, cardiovascular disease and other diseases.
Elizabeth G Nabel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Drug discovery     Volume:  1     ISSN:  1474-1776     ISO Abbreviation:  Nat Rev Drug Discov     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2002-12-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101124171     Medline TA:  Nat Rev Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-98     Citation Subset:  IM    
Cardiovascular Branch, National Heart, Lung and Blood Institute/National Institutes of Health, Building 10/8C103, 10 Center Drive, Bethesda, Maryland 20892, USA.
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MeSH Terms
Cyclin-Dependent Kinases / antagonists & inhibitors*,  metabolism
Cyclins / antagonists & inhibitors,  metabolism
Drug Delivery Systems / methods*
Enzyme Inhibitors / pharmacology*,  therapeutic use
Signal Transduction / drug effects,  physiology
Tissue Survival / drug effects*,  physiology
Reg. No./Substance:
0/Cyclins; 0/Enzyme Inhibitors; EC Kinases

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