Document Detail


CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells.
MedLine Citation:
PMID:  12196289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B cell terminal differentiation is associated with the onset of high-level antibody secretion and cell cycle arrest. Here the cyclin-dependent kinase (CDK) inhibitor p18(INK4c) is shown to be required within B cells for both terminating cell proliferation and differentiation of functional plasma cells. In its absence, B cells hyperproliferate in germinal centers and extrafollicular foci in response to T-dependent antigens but serum antibody titers are severely reduced, despite unimpaired germinal center formation, class switch recombination, variable region-directed hypermutation, and differentiation to antibody-containing plasmacytoid cells. The novel link between cell cycle control and plasma cell differentiation may, at least in part, relate to p18(INK4c) inhibition of CDK6. Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells.
Authors:
Michelle R Tourigny; Josie Ursini-Siegel; Hayyoung Lee; Kai-Michael Toellner; Adam F Cunningham; David S Franklin; Scott Ely; Meihong Chen; Xiao-Feng Qin; Yue Xiong; Ian C M MacLennan; Selina Chen-Kiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunity     Volume:  17     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-28     Completed Date:  2002-09-17     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-89     Citation Subset:  IM    
Affiliation:
Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation
Antigens, CD40 / immunology
Apoptosis
Cell Cycle
Cell Cycle Proteins*
Cell Differentiation
Cell Division
Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinases / antagonists & inhibitors*
Enzyme Inhibitors / immunology*
Germinal Center
Mice
Mice, Knockout
Plasma Cells / cytology*,  immunology
Protein-Serine-Threonine Kinases / antagonists & inhibitors*
Signal Transduction / immunology
Tumor Suppressor Proteins / genetics,  immunology*
Grant Support
ID/Acronym/Agency:
CA80204/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD40; 0/Cdkn2c protein, mouse; 0/Cell Cycle Proteins; 0/Cyclin-Dependent Kinase Inhibitor p18; 0/Enzyme Inhibitors; 0/Tumor Suppressor Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.22/Cdk6 protein, mouse; EC 2.7.11.22/Cyclin-Dependent Kinase 6; EC 2.7.11.22/Cyclin-Dependent Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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