Document Detail


CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside.
MedLine Citation:
PMID:  10378797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Signal transduction for apoptosis or programmed cell death, after DNA damage in mammalian cells, is believed to involve activation of cyclin-dependent kinases (CDKs), especially CDK-1 (cdc2) and CDK-2. We used CDK-inhibitor olomoucine, a purine analogue to evaluate the role CDK inhibition on cytosine-arabinoside (Ara-C)-induced cell death. The two drugs showed an antagonistic effect, suggesting that apoptosis after exposure to Ara-C is inhibited by olomoucine. DNA-electrophoresis showed a clear inhibition of the apoptotic pattern when olomoucine was added to Ara-C. We conclude that CDK-inhibitor olomoucine inhibits cell death induced by Ara-C.
Authors:
K T Papazisis; G D Geromichalos; D Kouretas; K A Dimitriadis; A H Kortsaris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  138     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-01     Completed Date:  1999-07-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Affiliation:
Theagenion Cancer Hospital, Thessaloniki, Greece. paptsi@med.auth.gr
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites, Antineoplastic / pharmacology*
Apoptosis / drug effects*
Cyclin-Dependent Kinases / antagonists & inhibitors*
Cytarabine / pharmacology*
DNA / biosynthesis
DNA Fragmentation / drug effects
Enzyme Inhibitors / pharmacology*
Hela Cells
Humans
Kinetin
Purines / pharmacology*
Signal Transduction
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Enzyme Inhibitors; 0/Purines; 0/olomoucine; 147-94-4/Cytarabine; 525-79-1/Kinetin; 9007-49-2/DNA; EC 2.7.11.22/Cyclin-Dependent Kinases
Comments/Corrections
Erratum In:
Cancer Lett 2000 Feb 28;149(1-2):227

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