Document Detail

The CDH Study Group and advances in the clinical care of the patient with congenital diaphragmatic hernia.
MedLine Citation:
PMID:  15283097     Owner:  NLM     Status:  MEDLINE    
Congenital diaphragmatic hernia (CDH) occurs in 1 of every 2000 to 4000 births and accounts for 8% of all major congenital anomalies. Recurrence risk for a subsequent pregnancy is estimated at 2%. The mortality rate for CDH when diagnosed antenatally, varies with fetal age and with the presence or absence of hydramnios and degree of pulmonary hypoplasia. The prognosis has improved dramatically in recent years, primarily due to advances in neonatal and surgical interventions. Neonatal survival rates with an antenatal diagnosis now exceed 80% in some centers. Treatment for infants with CDH reflects other pediatric surgical problems in that a majority of the clinical research that shapes treatment is retrospective in nature. Because CDH is a relatively rare disease, using a compilation of cases, such as the CDH database provides, greatly aids our understanding of this disease process. Moreover, the application of a quality assessment scale provides the practitioner with a knowledge base to critically evaluate the published retrospective data.
Nora M Doyle; Kevin P Lally
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  28     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-10-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-84     Citation Subset:  IM    
Division of Maternal Fetal Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, USA.
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MeSH Terms
Betamethasone / administration & dosage
Extracorporeal Membrane Oxygenation
Glucocorticoids / administration & dosage
Hernia, Diaphragmatic / congenital*,  diagnosis,  therapy*
Infant, Newborn
Pulmonary Surfactants / administration & dosage
Pulmonary Ventilation
Ultrasonography, Prenatal
Reg. No./Substance:
0/Glucocorticoids; 0/Pulmonary Surfactants; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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