| CDC25 Phosphatase Inhibitors: An Update. | |
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MedLine Citation:
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PMID: 22070688 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The cell division cycle 25 (CDC25) family of proteins is a group of highly conserved dual-specificity phosphatases. They are key regulators of normal cell division and the cell response to DNA damage, and play a fundamental role in transitions between cell cycle phases during normal cell division, via the activation of CdK/cyclin complexes. Their abnormal expression, detected in a number of tumors, often correlated with a poor clinical prognosis, implies that their dysregulation is involved in malignant transformation. Thus, inhibition of these proteins represents an attractive therapeutic target in oncology, as evidenced from many patents and papers published on the subject in recent years. Hence, this review aims to provide an overview of recent developments in the field of CDC25 phosphatase inhibitor design since 2008. |
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Authors:
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Antonio Lavecchia; Carmen Di Giovanni; Ettore Novellino |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-28 |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: - ISSN: 1875-5607 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dipartimento di Chimica Farmaceutica e Tossicologica, "Drug Discovery" Laboratory, Universit00E0 di Napoli "Federico II", Facolt00E0 di Farmacia, via D. Montesano 49, I-80131 Napoli, Italy. lavecchi@unina.it. |
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