| CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification. | |
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MedLine Citation:
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PMID: 20703205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neural tube defects (NTDs) are serious birth defects that result from the failure of the neural tube to close in the cranial region (anencephaly) or more caudally along the spine (spina bifida) by the 28th day of gestation. Infants born with anencephaly usually die within a few days of birth, and those with spina bifida have life-long disabilities with varying degrees of paralysis. Currently, identified risk factors for NTDs include a mother who previously had an NTD-affected pregnancy, maternal diabetes, obesity, hyperthermia, certain antiseizure medications, genetic variants, race/ethnicity, and nutrition (particularly folic acid insufficiency). In the United States, during 1995-1996, approximately 4,000 pregnancies were affected by an NTD. This number declined to 3,000 pregnancies in 1999-2000 after fortification of enriched cereal grain products with folic acid was mandated. Worldwide, in 1998, approximately 300,000 births were affected by an NTD. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: MMWR. Morbidity and mortality weekly report Volume: 59 ISSN: 1545-861X ISO Abbreviation: MMWR Morb. Mortal. Wkly. Rep. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802429 Medline TA: MMWR Morb Mortal Wkly Rep Country: United States |
Other Details:
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Languages: eng Pagination: 980-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Folic Acid
/
adverse effects,
therapeutic use* Food, Fortified* Health Status Disparities Hispanic Americans Humans Neural Tube Defects / epidemiology, ethnology, prevention & control* Prevalence United States / epidemiology Vitamin B Complex / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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