Document Detail

CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker.
MedLine Citation:
PMID:  16972949     Owner:  NLM     Status:  MEDLINE    
Atypical fibroxanthoma (AFX), a benign lesion, and pleomorphic malignant fibrous histiocytoma (MFH) are thought to represent points along the same neoplastic spectrum but with different prognoses and treatments. Diagnosis based on histology and clinical parameters alone is sometimes difficult, and a reliable cost-effective immunohistochemical marker to help distinguish these lesions would be beneficial. The diagnosis of AFX or MFH was based upon published clinical and microscopic criteria. Formalin-fixed, paraffin-embedded tissues of 17 cases of AFX and 26 cases of MFH were immunostained with monoclonal antibody to CD99. For all cases, CD99 expression was scored on a four-tiered scale: negative, weak (1+), moderate (2+), or strong (3+). Two pathologists blinded to tumor diagnoses and type of immunostain evaluated each case independently. The interobserver correlation coefficient was calculated. Seventeen patients with AFX (16 males and one female; mean age = 79) and 26 patients with MFH (16 males and 10 females; mean age = 60) were included. AFX lesions were from the head and the face, mean size = 1.5 cm, and MFH lesions were from the head, the neck, the trunk, and the upper/lower extremities, mean size = 5.2 cm. The 17 cases of AFX demonstrated moderate or strong (2 to 3+) immunoreactivity with CD99, compared to nine of 26 (35%) MFH cases (chi-square = 18.38; p < 0.001; interobserver correlation coefficient = 0.83). Of these, 16 of 17 (94%) AFX cases stained diffusely with CD99, while only four of 26 (15%) MFH cases stained diffusely. Control slides were adequate. Our study demonstrated that CD99 can help distinguish AFX from MFH, in addition to other immunohistochemistry as well as clinical and histologic criteria.
Paul H Hartel; Jeffrey Jackson; Barbara S Ducatman; Peilin Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  33 Suppl 2     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-15     Completed Date:  2007-04-05     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Department of Pathology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA.
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MeSH Terms
Aged, 80 and over
Antigens, CD / biosynthesis*,  immunology
Cell Adhesion Molecules / biosynthesis*,  immunology
Diagnosis, Differential
Fibroma / immunology,  metabolism*,  pathology*
Gene Expression Regulation, Neoplastic*
Histiocytoma, Malignant Fibrous / immunology,  metabolism*,  pathology*
Middle Aged
Tumor Markers, Biological / biosynthesis*,  immunology
Xanthomatosis / immunology,  metabolism*,  pathology*
Reg. No./Substance:
0/Antigens, CD; 0/CD99 protein, human; 0/Cell Adhesion Molecules; 0/Tumor Markers, Biological

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