| CD95-mediated apoptosis: no variation in cellular sensitivity during cell cycle progression. | |
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MedLine Citation:
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PMID: 9720915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sensitivity of CD95-mediated apoptosis has been reported to vary during cell cycle progression (FEBS Lett. (1997) 412, 91-93). Here, we report that three human glioma cell lines with different p53 status (i) undergo growth arrest and synchronous cell cycle re-entry after prolonged serum deprivation, (ii) do not exhibit cell cycle-related changes in CD95 expression at the cell surface, and (iii) do not exhibit cell cycle-related changes in susceptibility to DC95 ligand-induced apoptosis. In contrast, cell cycle-specific activity was demonstrated for various cancer chemotherapy drugs. Further, CD95 expression and susceptibility to CD95 ligand-induced apoptosis does not vary during cell cycle progression of Jurkat T cells, HeLa cervical carcinoma and HepG2 hepatocellular carcinoma cells. These results do not support a role for the cell cycle phase as an important predictor of vulnerability to CD95-mediated apoptosis. |
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Authors:
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A Hueber; S Durka; M Weller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 432 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-18 Completed Date: 1998-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 155-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Tübingen, School of Medicine, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
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pharmacology Antigens, CD95 / drug effects, genetics, physiology* Antineoplastic Agents / pharmacology Antineoplastic Agents, Phytogenic Aphidicolin / pharmacology Apoptosis / drug effects, immunology*, physiology Camptothecin / pharmacology Cell Cycle / drug effects, physiology Cell Death / drug effects Cisplatin / pharmacology Culture Media, Serum-Free / pharmacology Doxorubicin / pharmacology Enzyme Inhibitors / pharmacology Fas Ligand Protein Gene Expression / genetics Hela Cells Humans Hydroxyurea / pharmacology Jurkat Cells / cytology, drug effects, metabolism Membrane Glycoproteins / pharmacology Nimustine / pharmacology Nocodazole / pharmacology Paclitaxel / pharmacology Sensitivity and Specificity Teniposide / pharmacology Tumor Cells, Cultured / cytology, drug effects, metabolism Vincristine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antigens, CD95; 0/Antineoplastic Agents; 0/Antineoplastic Agents, Phytogenic; 0/Culture Media, Serum-Free; 0/Enzyme Inhibitors; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 127-07-1/Hydroxyurea; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 29767-20-2/Teniposide; 31430-18-9/Nocodazole; 33069-62-4/Paclitaxel; 38966-21-1/Aphidicolin; 42471-28-3/Nimustine; 57-22-7/Vincristine; 7689-03-4/Camptothecin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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