Document Detail


CD9 plays a role in Schwann cell migration in vitro.
MedLine Citation:
PMID:  7529830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify molecules that regulate Schwann cell migration, we have generated a panel of monoclonal antibodies against Schwann cell surface antigens that modulate Schwann cell migration in in vitro bioassays. One of these antibodies, SMRA1, recognizes a 26 kDa Schwann cell surface membrane protein identified here as CD9. SMRA1 enhances Schwann cell migration on two biologically relevant substrates: living axons of cultured dorsal root ganglion neurons, and cryostat sections of sciatic nerve. This CD9-induced regulation of Schwann cell motility is correlated with a rise in cytosolic calcium and enhanced tyrosine phosphorylation of several Schwann cell proteins. These results, together with the findings of Hadjiargyrou and Patterson (1994), implicate CD9 as an important regulator of Schwann cell behavior in peripheral nerve.
Authors:
E S Anton; M Hadjiargyrou; P H Patterson; W D Matthew
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  15     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-16     Completed Date:  1995-02-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  584-95     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal
Antigens, CD / physiology*
Antigens, Surface / immunology
Axons / physiology
Calcium / metabolism
Cell Movement / physiology
Immunohistochemistry
Intracellular Membranes / metabolism
Membrane Glycoproteins / physiology
Phosphotyrosine
Rats
Schwann Cells / immunology,  physiology*
Sciatic Nerve / physiology
Substrate Specificity
Tyrosine / analogs & derivatives,  metabolism
Grant Support
ID/Acronym/Agency:
NS02253/NS/NINDS NIH HHS; NS30216/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antigens, Surface; 0/CD9 antigen; 0/Membrane Glycoproteins; 21820-51-9/Phosphotyrosine; 55520-40-6/Tyrosine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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