Document Detail


CD8(+) Sézary syndrome with IL-22 production modulated by bacterial sepsis.
MedLine Citation:
PMID:  23013419     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Patients with Sézary syndrome are susceptible to bacterial sepsis, as cutaneous T-cell lymphoma (CTCL) can be driven by a superantigen-stimulated clonal proliferation of T cells.(1, 2) Recently, it has been reported that IL-22 plays an important role in innate immunity to regulate early defense mechanisms against attaching and effacing bacterial pathogens.(3) Here, we report a case of Sézary syndrome characterized by a high frequency of circulating IL-22-producing CD8(+) tumour cells under a condition of bacterial sepsis.
Authors:
T Shimauchi; K Sasada; Y Kito; T Mori; M Hata; T Fujiyama; T Ito; S Hirakawa; Y Tokura
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Publication Detail:
Type:  LETTER     Date:  2012-9-26
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Affiliation:
Department of Dermatology, Hamamatsu University School of Medicine Section of Dermatology, Numazu City Hospital.
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