| CD8-mediated inflammatory central nervous system disorders. | |
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MedLine Citation:
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PMID: 22547102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: In central nervous system (CNS) autoimmune disorders, CD8+ T cells have been reported to exert cytotoxic as well as regulatory functions. In virus-induced (meningo) encephalitis, they are essential for viral clearance, but can also cause severe immunopathology. This review aims to summarize the multifaceted roles CD8+ T cells can play in inflammatory CNS disorders. RECENT FINDINGS: Recent evidence for a role of CD8+ T cells in multiple sclerosis comes from genetic association studies confirming a protective effect of the HLA-A0201 allele. Besides their dominance in white matter lesions, CD8+ T cells contribute to immune infiltrates in cortical demyelinating lesions. Having infiltrated the CNS, CD8+ T cells migrate along an inflammation-induced fibrous network. Although CD8+ T cells are generally considered to be crucial for acute viral clearance, they can also induce autoimmune-like immunopathology by, for example, encountering a virus in adulthood while being at the same time latently infected by a related virus. Inadequate control of latent viruses under immunosuppressive treatments or immunodeficiencies is becoming increasingly important in neurology clinical work. SUMMARY: Future research should aim at identifying the specificity and functional phenotype of brain-infiltrating CD8+ T cells in autoimmune diseases and viral immunopathology in order to develop therapeutic strategies specifically targeting CNS-relevant immune reactions. |
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Authors:
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Anne Willing; Manuel A Friese |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in neurology Volume: 25 ISSN: 1473-6551 ISO Abbreviation: Curr. Opin. Neurol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-01 Completed Date: 2012-08-31 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 9319162 Medline TA: Curr Opin Neurol Country: England |
Other Details:
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Languages: eng Pagination: 316-21 Citation Subset: IM |
Affiliation:
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Institut für Neuroimmunologie und Klinische MS-Forschung, Zentrum für Molekulare Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Falkenried, Hamburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases of the Nervous System
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immunology* CD8-Positive T-Lymphocytes / physiology* Cell Differentiation Cell Movement Central Nervous System Diseases / complications, immunology*, pathology, virology Humans |
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