Document Detail


CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.
MedLine Citation:
PMID:  19414746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effector CD8 T cell recruitment into the skin in response to Ag challenge requires prior CXCL1/KC-directed neutrophil infiltration. Mechanisms inducing CXCL1 production and the dynamics of neutrophil-CD8 T cell interactions during elicitation of Ag-specific responses in the skin were investigated. CXCL1 and CXCL2/MIP-2 were produced within 3-6 h of Ag challenge at 10-fold higher levels in skin challenge sites of Ag-sensitized vs nonsensitized mice. In the challenge sites of sensitized mice this production decreased at 6-9 h postchallenge to near the levels observed in skin challenge sites of nonsensitized mice but rose to a second peak 12 h after challenge. The elevated early neutrophil chemoattractant production at 3-6 h after skin challenge of sensitized animals required both IFN-gamma and IL-17, produced by distinct populations of Ag-primed CD8 T cells in response to Ag challenge. Although induced by the Ag-primed CD8 T cells, the early CXCL1 and CXCL2 production was accompanied by neutrophil but not CD8 T cell infiltration into the skin Ag challenge site. Infiltration of the CD8 T cells into the challenge site was not observed until 18-24 h after challenge. These results demonstrate an intricate series of early interactions between Ag-specific and innate immune components that regulate the sequential infiltration of neutrophils and then effector T cells into the skin to mediate an immune response.
Authors:
Danielle D Kish; Xiaoxia Li; Robert L Fairchild
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  182     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-05-26     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5949-59     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adoptive Transfer
Animals
Antigens / immunology
CD8-Positive T-Lymphocytes / immunology*,  metabolism
Chemokine CXCL1 / biosynthesis,  immunology
Chemokine CXCL2 / biosynthesis,  immunology
Dermatitis, Contact / immunology*,  metabolism
Dinitrofluorobenzene / immunology
Female
Flow Cytometry
Gene Expression Profiling
Immunity, Innate*
Immunoassay
Immunohistochemistry
Interferon-gamma / biosynthesis*,  immunology
Interleukin-17 / biosynthesis*,  immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
Neutrophil Infiltration / immunology
Neutrophils / immunology,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Skin / immunology
Skin Tests
Grant Support
ID/Acronym/Agency:
R01 AI045888/AI/NIAID NIH HHS; R01 AI045888-09/AI/NIAID NIH HHS; R01 AI45888/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Chemokine CXCL1; 0/Chemokine CXCL2; 0/Interleukin-17; 82115-62-6/Interferon-gamma; D241E059U6/Dinitrofluorobenzene
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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