Document Detail

CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.
MedLine Citation:
PMID:  19414746     Owner:  NLM     Status:  MEDLINE    
Effector CD8 T cell recruitment into the skin in response to Ag challenge requires prior CXCL1/KC-directed neutrophil infiltration. Mechanisms inducing CXCL1 production and the dynamics of neutrophil-CD8 T cell interactions during elicitation of Ag-specific responses in the skin were investigated. CXCL1 and CXCL2/MIP-2 were produced within 3-6 h of Ag challenge at 10-fold higher levels in skin challenge sites of Ag-sensitized vs nonsensitized mice. In the challenge sites of sensitized mice this production decreased at 6-9 h postchallenge to near the levels observed in skin challenge sites of nonsensitized mice but rose to a second peak 12 h after challenge. The elevated early neutrophil chemoattractant production at 3-6 h after skin challenge of sensitized animals required both IFN-gamma and IL-17, produced by distinct populations of Ag-primed CD8 T cells in response to Ag challenge. Although induced by the Ag-primed CD8 T cells, the early CXCL1 and CXCL2 production was accompanied by neutrophil but not CD8 T cell infiltration into the skin Ag challenge site. Infiltration of the CD8 T cells into the challenge site was not observed until 18-24 h after challenge. These results demonstrate an intricate series of early interactions between Ag-specific and innate immune components that regulate the sequential infiltration of neutrophils and then effector T cells into the skin to mediate an immune response.
Danielle D Kish; Xiaoxia Li; Robert L Fairchild
Related Documents :
17557146 - Skin-induced tolerance and its reversal by toll-like receptor ligands.
2779476 - A mechanism of peripheral spread or localization of inflammatory reactions--role of the...
21030156 - Tranilast could has potential therapeutic value in the treatment of psoriasis.
10536996 - The roles of keratinocyte-derived cytokines in the epidermis and their possible respons...
19830456 - Activation of the immune system promotes insect dispersal in the wild.
19962976 - Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  182     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-05-26     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5949-59     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adoptive Transfer
Antigens / immunology
CD8-Positive T-Lymphocytes / immunology*,  metabolism
Chemokine CXCL1 / biosynthesis,  immunology
Chemokine CXCL2 / biosynthesis,  immunology
Dermatitis, Contact / immunology*,  metabolism
Dinitrofluorobenzene / immunology
Flow Cytometry
Gene Expression Profiling
Immunity, Innate*
Interferon-gamma / biosynthesis*,  immunology
Interleukin-17 / biosynthesis*,  immunology
Mice, Inbred BALB C
Mice, Knockout
Neutrophil Infiltration / immunology
Neutrophils / immunology,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Skin / immunology
Skin Tests
Grant Support
Reg. No./Substance:
0/Antigens; 0/Chemokine CXCL1; 0/Chemokine CXCL2; 0/Interleukin-17; 82115-62-6/Interferon-gamma; D241E059U6/Dinitrofluorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia.
Next Document:  Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosi...