Document Detail


CD73 and adenosine generation in the creation of regulatory microenvironments.
MedLine Citation:
PMID:  23199317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Conversely, the ATP metabolite adenosine is mainly an anti-inflammatory molecule. The ecto-enzymes CD39 and CD73 can dephosphorylate extracellular ATP to adenosine, thereby controlling this important pathway of immune modulation. Despite their established roles in the immune system, little is known of how CD39 and CD73 are themselves regulated. Recent data have shown that CD73 expression and adenosine generation are up-regulated by transforming growth factor-β, depending on the cytokine content of the local microenvironment. We review here these recent findings and discuss their implications in disease.
Authors:
F S Regateiro; S P Cobbold; H Waldmann
Related Documents :
23000207 - Emerging and critical issues in the pathogenesis of lupus.
23207767 - Hydroxyl radical (·oh) played a pivotal role in oridonin-induced apoptosis and autopha...
18371937 - Inhibition of the egf receptor blocks autocrine growth and increases the cytotoxic effe...
22985787 - The biological role of inflammation in atherosclerosis.
23000207 - Emerging and critical issues in the pathogenesis of lupus.
15295657 - Phenotypic changes and inflammatory cell distribution in the cornea during development ...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase / immunology,  metabolism*
Adenosine / biosynthesis*,  immunology
Adenosine Triphosphate / immunology,  metabolism
Animals
Antigens, CD / immunology
Apyrase / immunology
Cytokines / immunology,  metabolism
Humans
Inflammation Mediators / immunology,  metabolism
Mice
Signal Transduction / immunology
T-Lymphocytes, Regulatory / immunology,  metabolism
Transforming Growth Factor beta / immunology
Tumor Escape / immunology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Cytokines; 0/Inflammation Mediators; 0/Transforming Growth Factor beta; 8L70Q75FXE/Adenosine Triphosphate; EC 3.1.3.5/5'-Nucleotidase; EC 3.6.1.5/Apyrase; EC 3.6.1.5/CD39 antigen; K72T3FS567/Adenosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Productive activity and life satisfaction in korean elderly women.
Next Document:  Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?