| CD73 and adenosine generation in the creation of regulatory microenvironments. | |
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MedLine Citation:
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PMID: 23199317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Conversely, the ATP metabolite adenosine is mainly an anti-inflammatory molecule. The ecto-enzymes CD39 and CD73 can dephosphorylate extracellular ATP to adenosine, thereby controlling this important pathway of immune modulation. Despite their established roles in the immune system, little is known of how CD39 and CD73 are themselves regulated. Recent data have shown that CD73 expression and adenosine generation are up-regulated by transforming growth factor-β, depending on the cytokine content of the local microenvironment. We review here these recent findings and discuss their implications in disease. |
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Authors:
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F S Regateiro; S P Cobbold; H Waldmann |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 171 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-03 Completed Date: 2013-02-19 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
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Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase
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immunology,
metabolism* Adenosine / biosynthesis*, immunology Adenosine Triphosphate / immunology, metabolism Animals Antigens, CD / immunology Apyrase / immunology Cytokines / immunology, metabolism Humans Inflammation Mediators / immunology, metabolism Mice Signal Transduction / immunology T-Lymphocytes, Regulatory / immunology, metabolism Transforming Growth Factor beta / immunology Tumor Escape / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cytokines; 0/Inflammation Mediators; 0/Transforming Growth Factor beta; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; EC 3.1.3.5/5'-Nucleotidase; EC 3.6.1.5/Apyrase; EC 3.6.1.5/CD39 antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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