Document Detail


CD7-positive acute myeloid leukemia: further evidence of cellular immaturity.
MedLine Citation:
PMID:  1374757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among 63 cases of acute myeloid leukemia (AML), 14 were found to express the CD7 antigen, a cell surface marker usually found at an early stage during T lineage differentiation. The CD7-positive AML cases consisted of 5 cases of M1, 3 cases of M2, 3 cases of M4, 1 case of M5, 1 case of M6 and 1 case of M7. Among these 63 cases, the proportion of blast cells expressing the CD34 antigen was examined. The proportion of CD34-stained cells among the CD7-positive AML cases, although varying, was significantly larger than that among the CD7-negative AML cases (P less than 0.05). As the CD34 antigen was expressed on hematopoietic progenitor cells and was considered to reflect an early hematopoietic stage, the high proportion of cells expressing CD34 among the CD7-positive AML cases may support the notion that CD7-positive AML cells are immature.
Authors:
S Kondo; S Okamura; N Harada; W Ikematsu; C Kawasaki; T Fukuda; A Kubota; K Shimoda; M Harada; T Shibuya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  118     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  386-8     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD / analysis*
Antigens, CD34
Antigens, CD7
Antigens, Differentiation, T-Lymphocyte / analysis*
Female
Humans
Leukemia, Myeloid, Acute / immunology*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, CD7; 0/Antigens, Differentiation, T-Lymphocyte

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