| CD7(-) T cells are late memory cells generated from CD7(+) T cells. | |
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MedLine Citation:
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PMID: 18593274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD7(-) T cells constitute a distinct subset within the CD4(+) and CD8(+) T cell populations; their developmental and functional relationship to the majority of CD7(+) T cells, however, remained so far unresolved. We here elucidate that CD7(-) cells represent aging T cells in late memory cell development characterized by a high activation threshold, low effector capacities, and high sensitivity to activation-induced cell death (AICD). In this regard, CD7(-) T cells highly express killer cell lectin-like receptor G1 (KLRG-1), harbor telomeres of shorter lengths, a decreased telomerase expression per cell, and less amounts of T cell receptor rearrangement excision circles (TRECs) compared to CD7(+) cells. CD7(-) T cells are generated in vitro from naive CD7(+) T cells upon repetitive TCR/CD28 engagement, a process that is unidirectional and requires multiple cell divisions. Consequently, clonal expansions of CD7(-) T cells in vivo are less frequent than of CD7(+) T cells, the former can be traced back to those of CD7(+) T cells. |
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Authors:
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Gunter Rappl; David Schrama; Andreas Hombach; Eva Katharina Meuer; Annette Schmidt; Jürgen C Becker; Hinrich Abken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rejuvenation research Volume: 11 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 543-56 Citation Subset: IM |
Affiliation:
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Tumorgenetics, Department of Internal Medicine I, University of Cologne, Cologne, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD28 / physiology Antigens, CD45 / analysis Antigens, CD7 / analysis* Apoptosis Humans Immunologic Memory* Receptors, Antigen, T-Cell / physiology T-Lymphocyte Subsets / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD28; 0/Antigens, CD7; 0/Receptors, Antigen, T-Cell; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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