| CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. | |
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MedLine Citation:
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PMID: 12480696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole. |
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Authors:
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Todd A Fehniger; Megan A Cooper; Gerard J Nuovo; Marina Cella; Fabio Facchetti; Marco Colonna; Michael A Caligiuri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2002-12-12 |
Journal Detail:
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Title: Blood Volume: 101 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-03 Completed Date: 2003-06-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 3052-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH 43210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / analysis Antigens, CD56 / analysis* CD4-Positive T-Lymphocytes / drug effects, secretion* Cells, Cultured / immunology Coculture Techniques Humans Immunity, Cellular* Immunity, Innate* Interferon-gamma / biosynthesis, secretion* Interleukin-2 / physiology*, secretion Killer Cells, Natural / drug effects*, immunology Lymph Nodes / cytology*, immunology Lymphocyte Subsets / drug effects*, immunology Models, Immunological Receptors, Interleukin-2 / drug effects, physiology Tetanus Toxoid / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA65670/CA/NCI NIH HHS; CA68458/CA/NCI NIH HHS; P30CA16058/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD56; 0/Interleukin-2; 0/Receptors, Interleukin-2; 0/Tetanus Toxoid; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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