| CD56+ cells are recruited to the uterus in two waves: at ovulation and during the first 2 weeks after missed menses. | |
| | |
MedLine Citation:
|
PMID: 18076635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PROBLEM: Uterine natural killer (uNK) cells are enriched in the post-ovulatory uterus and during pregnancy. Whether these cells arise from blood pre-cursors or from stem cells in the uterus is undefined. To support a hypothesis that precursors of uNK cells are recruited from blood, adhesive function of blood CD56+ subsets were assessed during one cycle and during pregnancy. METHOD OF STUDY: Fifteen women of proven fertility provided serial blood samples during one menstrual cycle and thirty women with a history of implantation failure or recurrent spontaneous abortion provided serial samples during infertility treatment. RESULTS: CD56(bright) cells, but not CD56(dim) cells or NKT cells, increased in ligand-binding capacity during ovulation in fertile cycles only and during the first 2 weeks from date of missed menses. CONCLUSION: Enhanced adhesive function at ovulation in CD56(bright) cells in fertile cycles and during early gestation supports a hypothesis of recruitment of pre-uNK cells from the blood CD56(bright) subset. |
| | |
Authors:
|
Marianne J van den Heuvel; Kota Hatta; Crystal G Peralta; Victor K Han; David A Clark |
Related Documents
:
|
2940105 - The relationship between chromosomal origins of replication and the nuclear matrix duri... 12796285 - Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of candida a... 20053685 - Fate specification and tissue-specific cell cycle control of the caenorhabditis elegans... 563765 - Radiorespirometry of candida utilis in phased culture under nitrogen-, carbon-, and pho... 9067775 - Development of hassall's bodies of the thymus in humans and other vertebrates (especial... 17764075 - Reversible effect of x-irradiation on proliferation, neurogenesis, and cell death in th... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-21 |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 59 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-23 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 90-8 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Children's Health Research Institute, University of Western Ontario, London, ON, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, CD56 / immunology* Cell Adhesion / immunology Female Flow Cytometry Humans Infertility, Female / immunology* Lymphocyte Subsets / immunology Menstrual Cycle / immunology* Mice Mice, Inbred C57BL Microscopy, Fluorescence Ovulation / immunology* Pregnancy Uterus / cytology, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD56 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibody to the Chlamydia trachomatis 60 kDa heat shock protein in follicular fluid and in vitro fer...
Next Document: RCAS1 decidual immunoreactivity and RCAS1 serum level during cesarean section with respect to the pr...