Document Detail

CD56 as a useful marker in the regenerative process of the histological progression of primary biliary cirrhosis.
MedLine Citation:
PMID:  18794596     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Owing to recent contradicting results in the study of the regenerative process after hepatic injury in primary biliary cirrhosis, we investigated the use of CD56 in tissue repair during the histological progression of primary biliary cirrhosis. METHODS: Fifty-three specimens were classified into Ludwig's stages (1-4) as follows: 14 specimens as stage 1, 23 as stage 2, 14 as stage 3, and two as stage 4. Immunohistochemical stain was performed for CD56. The cell types expressing the marker were morphologically analyzed to determine their origin. RESULTS: In normal liver biliary epithelial cells (including the epithelium of terminal bile ducts and bile ductules), hepatocytes, and intermediate cells (features between hepatocytes and biliary cells, distributed in interface between hepatic parenchyma and portal tract) were CD56. In primary biliary cirrhosis specimens, biliary epithelial cells, hepatocytes, and intermediate cells were CD56 distributed as 10 out of 14 cases as stage 1 (71.43%), 18 out of 23 as stage 2 (78.26%), nine out of 14 as stage 3 (64.28%), and two out of two as stage 4 (100%). The total positive cases were 39 of 53 (73.58%). CD56 was expressed equally in all three types of cells. CONCLUSION: These findings indicate that the consistent and uniform expression of CD56 in biliary epithelial cells, hepatocytes, and intermediate cells during hepatic injury in primary biliary cirrhosis is probably related to cellular damage and may be important in tissue regeneration. Furthermore, we cannot distinguish a specific cell type from the three above mentioned ones (biliary epithelial cells, hepatocytes, intermediate cells) as a putative stem cell in primary biliary cirrhosis.
Paschalis Chatzipantelis; Andreas C Lazaris; Georgia Kafiri; Aphrodite Nonni; Konstantina Papadimitriou; Konstantinos Xiromeritis; Efstratios S Patsouris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  20     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-12-29     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Department of Pathology, Hippokration General Hospital of Athens, Athens, Greece.
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MeSH Terms
Antigens, CD56 / analysis*,  physiology
Bile Ducts, Intrahepatic / chemistry
Biological Markers / analysis
Disease Progression
Epithelial Cells / chemistry
Hepatocytes / chemistry
Liver / chemistry
Liver Cirrhosis, Biliary / metabolism*,  pathology,  physiopathology
Liver Regeneration*
Retrospective Studies
Severity of Illness Index
Reg. No./Substance:
0/Antigens, CD56; 0/Biological Markers

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