Document Detail

CD5 signal transduction: positive or negative modulation of antigen receptor signaling.
MedLine Citation:
PMID:  11100806     Owner:  NLM     Status:  MEDLINE    
The CD5 lymphocyte surface glycoprotein is a coreceptor involved in the modulation of antigen-specific receptor-mediated activation and differentiation signals. Although first considered a costimulatory molecule in mature peripheral T cells, recent studies of CD5-/- mice have opened the possibility that CD5 may also mediate inhibitory signals that attenuate TCR/CD3- and BCR-mediated triggering in thymocytes and a subgroup of B cells (B-1a cells), respectively. The ultimate molecular basis for these differential modulatory properties of CD5, depending on the context of lymphocyte subset and differentiation stage, are presently unknown and are an issue of current intensive investigation. Here, we review recent reports, both contradictory and complementary, focused on CD5-mediated molecular intracellular signaling events that could provide the basis for its immunomodulatory properties.
F Lozano; M Simarro; J Calvo; J M Vilà; O Padilla; M A Bowen; K S Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Critical reviews in immunology     Volume:  20     ISSN:  1040-8401     ISO Abbreviation:  Crit. Rev. Immunol.     Publication Date:  2000  
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8914819     Medline TA:  Crit Rev Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-58     Citation Subset:  IM    
Servei d'Immunologia, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel, Barcelona, Spain.
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MeSH Terms
Antigens, CD5 / physiology*
MAP Kinase Signaling System
Protein Kinase C / physiology
Protein Tyrosine Phosphatases / physiology
Protein-Serine-Threonine Kinases / physiology
Protein-Tyrosine Kinases / physiology
Receptors, Antigen, B-Cell / physiology*
Receptors, Antigen, T-Cell / physiology*
Signal Transduction*
Grant Support
Reg. No./Substance:
0/Antigens, CD5; 0/Receptors, Antigen, B-Cell; 0/Receptors, Antigen, T-Cell; EC Kinases; EC Kinases; EC Kinase C; EC Tyrosine Phosphatases

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