Document Detail


CD5-positive B-cell acute lymphoblastic leukemia.
MedLine Citation:
PMID:  17378623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD5-positive B-cell acute lymphoblastic leukemia (ALL) is an exceedingly rare entity, with only a single case report in the literature. We report 2 additional cases of CD5-positive B-cell ALL in a 16-year-old male and a 15-year-old female. The 1st case was initially misdiagnosed as Ewing sarcoma due to a lack of CD45 expression and weak expression of CD99. Cytogenetic analysis of the 2nd case revealed trisomy 22, the 1st time this finding has been reported in ALL. Both patients had poor outcomes, as did the patient in the previously published case report. We conclude that CD5-positive B-cell ALL is a rare, aggressive malignancy with a poor prognosis that presents in adolescence. Pathologists and clinicians should be aware of this entity to avoid confusion with other small blue-cell tumors.
Authors:
Michael R Peterson; Kyle J Noskoviak; Robert Newbury
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  10     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-03-23     Completed Date:  2007-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of California, San Diego, and Children's Hospital and Health Center of San Diego, CA 92123, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antigens, CD / metabolism
Antigens, CD5 / metabolism*
Biopsy
Bone Marrow / pathology,  surgery
Burkitt Lymphoma / metabolism*,  pathology*
Diagnosis, Differential
Diagnostic Errors
Female
Flow Cytometry
Humans
Immunohistochemistry
Leukemia / pathology
Lymphoma / pathology
Male
Prognosis
Sarcoma / pathology
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD5; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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