Document Detail

CD5+ follicular lymphoma: a clinicopathologic study of three cases.
MedLine Citation:
PMID:  12375647     Owner:  NLM     Status:  MEDLINE    
Follicular lymphoma (FL) is a low-grade lymphoma that typically lacks CD5 antigen expression. We report 3 cases of FL with unusual expression of CD5. All cases showed histologic features of FL, including effaced nodal architecture, follicular growth pattern, and a spectrum of grades from 1 to 3 using World Health Organization criteria. In flow cytometric studies, all 3 cases showed a light chain-restricted, CD19+, CD20+ B-cell population coexpressing CD10 and low-level CD5. Immunohistochemical studies demonstrated an identical B-cell immunophenotype with weak expression of CD5 and coexpression of bcl-2 protein and the germinal center-associated markers, CD10 and bcl-6 protein. None of the cases showed expression of CD43, cyclin D1, or IgD. By molecular analysis, immunoglobulin heavy chain gene rearrangements were demonstrated in all 3 cases, and 2 of 3 cases had a t(14;18). These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas.
Todd S Barry; Elaine S Jaffe; Douglas W Kingma; Alvin W Martin; Lynn Sorbara; Mark Raffeld; Stefania Pittaluga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  118     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-11     Completed Date:  2002-10-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-98     Citation Subset:  AIM; IM    
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Antigens, CD5 / metabolism*
B-Lymphocytes / metabolism,  pathology
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA, Neoplasm / analysis
DNA-Binding Proteins / metabolism
Flow Cytometry
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Immunoglobulin Light Chains / metabolism
Lymphoma, Follicular / genetics,  metabolism*,  pathology*
Middle Aged
Neprilysin / metabolism
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Proto-Oncogene Proteins c-bcl-6
Transcription Factors / metabolism
Translocation, Genetic
Reg. No./Substance:
0/Antigens, CD5; 0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/Immunoglobulin Light Chains; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Proto-Oncogene Proteins c-bcl-6; 0/Transcription Factors; EC

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