| CD5+ follicular lymphoma: a clinicopathologic study of three cases. | |
| | |
MedLine Citation:
|
PMID: 12375647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Follicular lymphoma (FL) is a low-grade lymphoma that typically lacks CD5 antigen expression. We report 3 cases of FL with unusual expression of CD5. All cases showed histologic features of FL, including effaced nodal architecture, follicular growth pattern, and a spectrum of grades from 1 to 3 using World Health Organization criteria. In flow cytometric studies, all 3 cases showed a light chain-restricted, CD19+, CD20+ B-cell population coexpressing CD10 and low-level CD5. Immunohistochemical studies demonstrated an identical B-cell immunophenotype with weak expression of CD5 and coexpression of bcl-2 protein and the germinal center-associated markers, CD10 and bcl-6 protein. None of the cases showed expression of CD43, cyclin D1, or IgD. By molecular analysis, immunoglobulin heavy chain gene rearrangements were demonstrated in all 3 cases, and 2 of 3 cases had a t(14;18). These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas. |
| | |
Authors:
|
Todd S Barry; Elaine S Jaffe; Douglas W Kingma; Alvin W Martin; Lynn Sorbara; Mark Raffeld; Stefania Pittaluga |
Related Documents
:
|
20538427 - Head and neck non-hodgkin's lymphoma: a 20-year demographic study of 381 cases. 8092107 - Hypersensitivity reactions to etoposide. a report of three cases and review of the lite... 512487 - Lennert's lymphoma (lympho-epithelioid cellular lymphoma). 15226567 - Osteosarcoma of the rib. 21772807 - Major intratumoral hemorrhage of a petroclival atypical meningioma: case report and rev... 21121757 - Management of an extensive spinal epidural abscess from c-1 to the sacrum. case report. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 118 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2002 Oct |
Date Detail:
|
Created Date: 2002-10-11 Completed Date: 2002-10-24 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 589-98 Citation Subset: AIM; IM |
Affiliation:
|
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antigens, CD5 / metabolism* B-Lymphocytes / metabolism, pathology Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 DNA, Neoplasm / analysis DNA-Binding Proteins / metabolism Female Flow Cytometry Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunoglobulin Light Chains / metabolism Lymphoma, Follicular / genetics, metabolism*, pathology* Male Middle Aged Neprilysin / metabolism Proto-Oncogene Proteins / metabolism Proto-Oncogene Proteins c-bcl-2 / metabolism Proto-Oncogene Proteins c-bcl-6 Transcription Factors / metabolism Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD5; 0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/Immunoglobulin Light Chains; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Proto-Oncogene Proteins c-bcl-6; 0/Transcription Factors; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with o...
Next Document: Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfus...