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CD4(+)CD28(null) T lymphocytes are expanded in young women with polycystic ovary syndrome.
MedLine Citation:
PMID:  21324454     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4(+)CD28(null) T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
Authors:
Giampaolo Niccoli; Rosanna Apa; Antonio Lanzone; Giovanna Liuzzo; Cristina Spaziani; Francesca Sagnella; Nicola Cosentino; Francesca Moro; Daniela Martinez; Andrea Morciano; Marco Bacà; Vincenzo Pazzano; Maria Francesca Gangale; Anna Tropea; Filippo Crea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-15
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
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