Document Detail


CD4+CD25high regulatory T cells in human autoimmune diabetes.
MedLine Citation:
PMID:  15725577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mouse models, CD4+CD25+ T cells are involved in maintenance of peripheral tolerance. In humans, a subset of CD4+CD25+ T cells expressing high levels of CD25 (CD4+CD25high) with characteristics identical to murine CD4+CD25+ was recently described. We evaluated the characteristics of CD4+CD25high T cells in peripheral blood of type 1 diabetic subjects (T1D) and normal controls (NC). In contrast to a previous report, we found no difference in the number of CD4+CD25high and CD4+CD25+ T cells between T1D and NC. We confirmed previous studies that demonstrated that human CD4+CD25high cells can suppress the proliferation of co-cultured CD4+CD25- cells stimulated in conditions of sub-maximal cross-linking by anti-CD3 either with or without anti-CD28. However, we did not observe statistical differences between the normal controls and the chronic diabetic subjects we tested. Culturing of these cell populations did not appear to affect their ability to suppress proliferation in both groups. In conclusion, we found no significant differences in number or in vitro regulatory function of CD4+CD25high in chronic human T1D subjects.
Authors:
Amy L Putnam; Francesco Vendrame; Francesco Dotta; Peter A Gottlieb
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-12
Journal Detail:
Title:  Journal of autoimmunity     Volume:  24     ISSN:  0896-8411     ISO Abbreviation:  J. Autoimmun.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Affiliation:
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD4 / immunology,  metabolism*
CD4-Positive T-Lymphocytes / cytology,  immunology*,  metabolism
Cell Proliferation
Cells, Cultured
Cytokines / metabolism
Diabetes Mellitus, Type 1 / immunology*,  metabolism,  pathology
Humans
Middle Aged
Receptors, Interleukin-2 / immunology,  metabolism*
Grant Support
ID/Acronym/Agency:
5 P30 CA046934-15/CA/NCI NIH HHS; P30-DK57516/DK/NIDDK NIH HHS; RR00051/RR/NCRR NIH HHS; RR0009/RR/NCRR NIH HHS; U01DK61926/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD4; 0/Cytokines; 0/Receptors, Interleukin-2

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