Document Detail

CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
MedLine Citation:
PMID:  18027108     Owner:  NLM     Status:  MEDLINE    
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Christian Mottet; Dela Golshayan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Swiss medical weekly     Volume:  137     ISSN:  1424-7860     ISO Abbreviation:  Swiss Med Wkly     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-01-24     Revised Date:  2011-02-15    
Medline Journal Info:
Nlm Unique ID:  100970884     Medline TA:  Swiss Med Wkly     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  625-34     Citation Subset:  IM    
Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Antigens, CD / immunology
Antigens, Differentiation / immunology
Forkhead Transcription Factors / immunology,  physiology*,  therapeutic use
Immune Tolerance / physiology
Interleukin-10 / immunology,  physiology
Interleukin-2 / immunology,  physiology
Receptors, Interleukin-2 / immunology,  physiology
T-Lymphocytes, Regulatory / immunology,  physiology*
Transforming Growth Factor beta / immunology,  physiology
Transplantation Immunology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-2; 0/Receptors, Interleukin-2; 0/Transforming Growth Factor beta; 0/cytotoxic T-lymphocyte antigen 4; 130068-27-8/Interleukin-10

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