Document Detail


CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
MedLine Citation:
PMID:  18027108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Authors:
Christian Mottet; Dela Golshayan
Related Documents :
16508968 - Vasoactive intestinal peptide induces cd4+,cd25+ t regulatory cells with therapeutic ef...
20347178 - Post-natal paucity of regulatory t cells and control of nk cell activation in experimen...
16585568 - Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced...
20082358 - C-rel but not nf-kappab1 is important for t regulatory cell development.
3492428 - Recombinant human granulocyte colony stimulating factor: molecular and biological chara...
8142648 - Establishment of two permanent human bone marrow stromal cell lines with long-term post...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Swiss medical weekly     Volume:  137     ISSN:  1424-7860     ISO Abbreviation:  Swiss Med Wkly     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-01-24     Revised Date:  2011-02-15    
Medline Journal Info:
Nlm Unique ID:  100970884     Medline TA:  Swiss Med Wkly     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  625-34     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. christian.mottet@chuv.ch
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / immunology
Antigens, Differentiation / immunology
Forkhead Transcription Factors / immunology,  physiology*,  therapeutic use
Humans
Immune Tolerance / physiology
Interleukin-10 / immunology,  physiology
Interleukin-2 / immunology,  physiology
Receptors, Interleukin-2 / immunology,  physiology
T-Lymphocytes, Regulatory / immunology,  physiology*
Transforming Growth Factor beta / immunology,  physiology
Transplantation Immunology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-2; 0/Receptors, Interleukin-2; 0/Transforming Growth Factor beta; 0/cytotoxic T-lymphocyte antigen 4; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of anchor-based and distributional approaches in estimating important difference in commo...
Next Document:  Reclassification and analysis of clinical significance of atypical glandular cells on ThinPrep using...