| CD46 plasticity and its inflammatory bias in multiple sclerosis. | |
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MedLine Citation:
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PMID: 21267793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Known as a link to the adaptive immune system, a complement regulator, a "pathogen magnet" and more recently as an inducer of autophagy, CD46 is the human receptor that refuses to be put in a box. This review summarizes the current roles of CD46 during immune responses and highlights the role of CD46 as both a promoter and attenuator of the immune response. In patients with multiple sclerosis (MS), CD46 responses are overwhelmingly pro-inflammatory with notable defects in cytokine and chemokine production. Understanding the role of CD46 as an inflammatory regulator is a distant goal considering the darkness in which its regulatory mechanisms reside. Further research into the regulation of CD46 expression through its internalization and processing will undoubtedly extend our knowledge of how the balance is tipped in favor of inflammation in MS patients. |
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Authors:
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Siobhan Ni Choileain; Anne L Astier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-01-26 |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: 59 ISSN: 1661-4917 ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-08 Completed Date: 2011-05-23 Revised Date: 2011-08-04 |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: Switzerland |
Other Details:
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Languages: eng Pagination: 49-59 Citation Subset: IM |
Affiliation:
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Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity Amyloid Precursor Protein Secretases / metabolism Animals Antigens, CD46 / metabolism* Autophagy Cell Movement Complement Activation Humans Inflammation Mediators / metabolism* Interleukins / metabolism Matrix Metalloproteinases / metabolism Multiple Sclerosis / immunology*, pathology Presenilins / metabolism T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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859//Multiple Sclerosis Society |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD46; 0/Inflammation Mediators; 0/Interleukins; 0/Presenilins; EC 3.4.-/Amyloid Precursor Protein Secretases; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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