Document Detail

CD40 expression in epidermal tumors.
MedLine Citation:
PMID:  9066581     Owner:  NLM     Status:  MEDLINE    
CD40 antigen, expressed on many cell types is involved in cell-cell interactions, with activated T cells expressing the CD40 ligand. In the skin, keratinocytes express CD40 which may play a role in amplifying inflammatory responses. We investigated the expression of this antigen in a series of epidermal tumors in correlation with T cell infiltrates. Our results indicate a-down-regulation or a drastic loss of CD40 antigen by tumor cells from basal cell carcinoma and squamous cell carcinoma and a moderate to discrete CD40 reactivity of keratinocyte from proliferative layers of benign viral-induced lesions. Endothelial cells, most infiltrating cells and a subpopulation of intraepidermal dendritic cells strongly expressed CD40, mainly in benign lesions, in which T cell-keratinocyte interactions may be observed, and were restricted to epithelial cells expressing CD40. The lack of CD40 expression by tumor cells might account for tumor escape mechanism from activated T cells expressing the CD40 ligand.
J Viac; D Schmitt; A Claudy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  569-72     Citation Subset:  IM    
INSERM U346 and Clinique Dermatologique, Hôpital E. Herriot, Lyon, France.
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MeSH Terms
Antigens, CD40 / analysis*
Antigens, Neoplasm / analysis*
Carcinoma, Basal Cell / immunology*
Carcinoma, Squamous Cell / immunology*
Condylomata Acuminata / immunology*
Skin Neoplasms / immunology*
Warts / immunology*
Reg. No./Substance:
0/Antigens, CD40; 0/Antigens, Neoplasm

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