Document Detail


CD40 and CD95 induce programmed cell death in the human myeloma cell line XG2.
MedLine Citation:
PMID:  9207415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously demonstrated that CD40 stimulation induced a cellular growth arrest of the highly CD40-positive myeloma cell line XG2. To further characterize this inhibition of proliferation, we looked for a possible induction of apoptosis. Since no DNA fragmentation could be detected, we used newly described techniques that enable detection of apoptosis independently of DNA degradation, i.e. supravital exposure to propidium iodide (PI) and Annexin V labelling. We demonstrated that CD40 effectively induced programmed cell death. Furthermore, we have shown that CD95 (Fas) stimulation significantly enhanced the CD40-induced apoptosis.
Authors:
A Bergamo; R Bataille; C Pellat-Deceunynck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  97     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-18     Completed Date:  1997-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  652-5     Citation Subset:  IM    
Affiliation:
U463 Inserm, Institut de Biologie, Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Annexin A5 / physiology
Antigens, CD40 / physiology*
Antigens, CD95 / physiology*
Apoptosis*
Cell Line
Humans
Multiple Myeloma / pathology*
Chemical
Reg. No./Substance:
0/Annexin A5; 0/Antigens, CD40; 0/Antigens, CD95

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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