| CD4 mimics targeting the mechanism of HIV entry. | |
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MedLine Citation:
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PMID: 19926478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A structure-activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change in gp120, exposing its co-receptor-binding site. This induces a highly synergistic interaction in the use in combination with a co-receptor CXCR4 antagonist and reveals a pronounced effect on the dynamic supramolecular mechanism of HIV-1 entry. |
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Authors:
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Yuko Yamada; Chihiro Ochiai; Kazuhisa Yoshimura; Tomohiro Tanaka; Nami Ohashi; Tetsuo Narumi; Wataru Nomura; Shigeyoshi Harada; Shuzo Matsushita; Hirokazu Tamamura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-04 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 354-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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chemical synthesis,
chemistry*,
pharmacology Antigens, CD4 / chemistry*, metabolism Binding Sites Cell Line HIV Envelope Protein gp120 / chemistry*, metabolism HIV Fusion Inhibitors / chemical synthesis, chemistry*, pharmacology Humans Receptors, CXCR4 / antagonists & inhibitors, metabolism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antigens, CD4; 0/HIV Envelope Protein gp120; 0/HIV Fusion Inhibitors; 0/Receptors, CXCR4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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