Document Detail

CD4+ T-lymphocyte nadir and the effect of highly active antiretroviral therapy on phenotypic and functional immune restoration in HIV-1 infection.
MedLine Citation:
PMID:  11846457     Owner:  NLM     Status:  MEDLINE    
To evaluate the effects of the timing of highly active antiretroviral therapy (HAART) on immune reconstitution, we compared lymphocyte subpopulations and lymphocyte proliferation (LP) in response to Candida albicans, cytomegalovirus, HIV p24, Mycobacterium avium complex, pokeweed mitogen, streptokinase, and tetanus toxoid in 43 patients with pretherapy advanced, moderately advanced, and early chronic HIV-1 infection. All patients had recent CD4+ T-cell counts >450/microl and HIV RNA <400 copies/ml for >12 months. CD4+ nadirs were positively correlated with recent numbers of CD4+ T-cells (P < 0.001), memory cells (P < 0.001), and naïve CD4+ T-cells (P < 0.05) and CD4+ CD28+ T-lymphocytes (P < 0.05) and were negatively correlated with recent CD8+ T-lymphocyte counts (P < 0.05). Only CD4+ naïve T-cells normalized when HAART was initiated at lower CD4+ T-cell levels. Fifty-three percent of patients had LP responses to HIV p24 antigen. While LP responses to prevalent antigens were usually present, responses to tetanus toxoid were more common with higher CD4+ T-lymphocyte nadirs (P < 0.05). Delaying HAART may limit phenotypic and functional immune restoration in HIV-1 infection.
Christoph G Lange; Hernan Valdez; Kathy Medvik; Robert Asaad; Michael M Lederman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  102     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Elsevier Science (USA).
Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Antiretroviral Therapy, Highly Active*
CD4-Positive T-Lymphocytes / drug effects,  immunology*
Candida albicans / immunology
Cytomegalovirus / immunology
HIV Core Protein p24 / immunology
HIV Infections / drug therapy,  immunology*
HIV-1 / drug effects,  immunology*
Lymphocyte Activation / immunology
Middle Aged
Mycobacterium avium Complex / immunology
Pokeweed Mitogens / immunology
Streptokinase / immunology
T-Lymphocyte Subsets / immunology*
Tetanus Toxoid / immunology
Grant Support
Reg. No./Substance:
0/HIV Core Protein p24; 0/Pokeweed Mitogens; 0/Tetanus Toxoid; EC 3.4.-/Streptokinase

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