Document Detail

CD4 T cells in immunity and immunotherapy of Alzheimer's disease.
MedLine Citation:
PMID:  23534386     Owner:  NLM     Status:  MEDLINE    
Alzheimer's disease (AD) is the most common form of dementia, with prevalence progressively increasing with aging. Pathological hallmarks of the disease include accumulation of amyloid β-protein (Aβ) peptides and neurofibrillary tangles in the brain associated with glial activation and synaptotoxicity. In addition, AD involves peripheral and brain endogenous inflammatory processes that appear to enhance disease progression. More than a decade ago a new therapeutic paradigm emerged for AD, namely the activation of the adaptive immune system directly against the self-peptide Aβ, aimed at lowering its accumulation in the brain. This was the first time that a brain peptide was used to vaccinate human subjects in a manner similar to classic viral or bacterial vaccines. The vaccination approach has taken several forms, from initially active to passive and then back to modified active vaccines. As the first two approaches to date failed to show sufficient efficacy, the last is presently being evaluated in ongoing clinical trials. The present review summarizes the immunogenic characteristics of Aβ in humans and mice and discusses past, present and future Aβ-based immunotherapeutic approaches for AD. We emphasize potential pathogenic and beneficial roles of CD4 T cells in light of the pathogenesis and the general decline in T-cell responsiveness evident in the disease.
Alon Monsonego; Anna Nemirovsky; Idan Harpaz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology     Volume:  139     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-03     Completed Date:  2013-09-09     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  438-46     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Adaptive Immunity
Alzheimer Disease / immunology,  therapy*
Alzheimer Vaccines / therapeutic use*
Amyloid beta-Peptides / immunology*
CD4-Positive T-Lymphocytes / immunology*
Immunotherapy / methods*
Reg. No./Substance:
0/Alzheimer Vaccines; 0/Amyloid beta-Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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