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CD4(+) T-cell subsets in transplantation.
MedLine Citation:
PMID:  23405905     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The identification of T-helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD4(+) T cells has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many studies in animal models and clinical transplantation have demonstrated that interleukin-17 (IL-17) is involved in allograft rejection. It appears that Th17 cells together with Th1 and Th2 cells play an important role in mediating allograft rejection. Here, we summarize our current knowledge on the contribution of Th1, Th2, Th9, Th17, Th22, and follicular T-helper (Tfh) cells in allograft rejection. We also discuss the regulation of CD4(+) T-cell subsets by CD4(+) Foxp3(+) regulatory T cells (Tregs) in the context of transplantation tolerance.
Authors:
Zhongmin Liu; Huimin Fan; Shuiping Jiang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Affiliation:
Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital of Tongji University, Shanghai, China.
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