| CD4(+) T-cell subsets and host defense in the lung. | |
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MedLine Citation:
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PMID: 23405903 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CD4(+) T-helper subsets are lineages of T cells that have effector function in the lung and control critical aspects of lung immunity. Depletion of these cells experimentally or by drugs or human immunodeficiency virus (HIV) infection in humans leads to the development of opportunistic infections as well as increased rates of bacteremia with certain bacterial pneumonias. Recently, it has been proposed that CD4(+) T-cell subsets may also be excellent targets for mucosal vaccination to prevent pulmonary infections in susceptible hosts. Here, we review recent findings that increase our understanding of T-cell subsets and their effector cytokines in the context of pulmonary infection. |
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Authors:
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Jay K Kolls |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 252 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 156-63 Citation Subset: IM |
Copyright Information:
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© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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