Document Detail


CD4(+) T-cell subsets and host defense in the lung.
MedLine Citation:
PMID:  23405903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD4(+) T-helper subsets are lineages of T cells that have effector function in the lung and control critical aspects of lung immunity. Depletion of these cells experimentally or by drugs or human immunodeficiency virus (HIV) infection in humans leads to the development of opportunistic infections as well as increased rates of bacteremia with certain bacterial pneumonias. Recently, it has been proposed that CD4(+) T-cell subsets may also be excellent targets for mucosal vaccination to prevent pulmonary infections in susceptible hosts. Here, we review recent findings that increase our understanding of T-cell subsets and their effector cytokines in the context of pulmonary infection.
Authors:
Jay K Kolls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-63     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes / immunology*,  pathology
Coinfection
Cytokines / biosynthesis,  immunology
HIV Infections / immunology*,  pathology,  virology
Humans
Immunity, Mucosal
Lung / immunology*,  microbiology,  pathology,  virology
Mucous Membrane / immunology,  pathology
Opportunistic Infections / immunology*,  microbiology,  pathology
Pneumonia, Bacterial / immunology*,  microbiology,  pathology
T-Lymphocyte Subsets / immunology*,  pathology
Grant Support
ID/Acronym/Agency:
P30 DK072506/DK/NIDDK NIH HHS; P50 HL084932/HL/NHLBI NIH HHS; P50HL084932/HL/NHLBI NIH HHS; R01 HL061271/HL/NHLBI NIH HHS; R37 HL079142/HL/NHLBI NIH HHS; R37HL079142/HL/NHLBI NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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